Thursday, March 28, 2013

11 key moments from the argument over the Defense of Marriage Act

Justice Ruth Bader Ginsburg discusses federal benefits at Wednesday's Supreme Court hearing as they relate to the Defense of Marriage Act.

By Erin McClam, Staff Writer, NBC News

The Supreme Court on Wednesday appeared highly skeptical of the Defense of Marriage Act, the 1996 law that blocks federal recognition of gay marriages, according to courtroom observers.

Here are 11 key moments from the arguments, which followed Tuesday's session on California's ban on same-sex marriage. The two cases could reshape the legal status of hundreds of thousands of gay couples.

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1. Early in the proceedings, Vicki Jackson, a law professor appointed by the court to argue that it does not have the jurisdiction to decide the constitutionality of DOMA, makes the heart of her case:

Jackson: "While it is natural to want to reach the merits of such a significant issue, as in Raines v. Byrd, this natural urge must be put aside because, however important the constitutional question, Article III prevents its decision here and requires this Court to await another case, another day, to decide the question."

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2. Chief Justice John Roberts strongly takes issue with the Obama administration?s decision to continue enforcing DOMA while believing that it is unconstitutional -- and appears to question the courage of the president:

Roberts: "And if he has made a determination that executing the law by enforcing the terms is unconstitutional, I don't see why he doesn't have the courage of his convictions and execute not only the statute, but do it consistent with his view of the Constitution, rather than saying, oh, we'll wait till the Supreme Court tells us we have no choice."

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3. Justice Elena Kagan speaks of $300,000, an apparent reference to the $363,000 that Edith Windsor claims she had to pay in federal taxes on her late wife?s estate because of DOMA. She's addressing the issue of whether Windsor meets the legal standard of injury.

Kagan: "But, Ms. Jackson, I mean, to go back to Justice Kennedy's point, we have injury here in the most classic, most concrete sense. There's $300,000 that's going to come out of the government's treasury if this decision is upheld, and it won't if it isn't. Now, the Government is willing to pay that $300,000, would be happy to pay that $300,000, but whether the Government is happy or sad to pay that $300,000, the government is still paying the $300,000, which in the usual set of circumstances is the classic Article III injury."

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4. Roberts again takes issue with the administration?s decision to enforce DOMA while opposing it on constitutional grounds. He is addressing Deputy Solicitor General Sri Srinivasan, arguing for the administration:

Roberts: "So this is totally unprecedented. You're asking us to do something we have never done before to reach the issue in this case."

Srinivasan: "Let me say two things about that if I might, Your Honor. First is that it's -- it's unusual, but that's not at all surprising, because the -- "

Roberts: "No, it's not just -- it's not unusual. It's totally unprecedented."

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5. Later, as Roberts and Srinivasan continue to argue about the administration's enforcement of DOMA, Justice Antonin Scalia joins the fray:

Srinivasan: "But -- but my point is simply that when the president makes a determination that a statute is unconstitutional, it can follow that the Department of Justice won't defend it in litigation."

Roberts: "Sometimes you do and sometimes you don't. What is the test for when you think your obligation to take care that the laws be faithfully executed means you'll follow your view about whether it's constitutional or not or you won't follow your view?"

Srinivasan: "Mr. Chief Justice, I'd hesitate to give you a black-and-white algorithm. There are -- there are several considerations that would factor into it. One of the considerations --"

Scalia: "Excuse me. It's not your view. It's the president's. It's only when the president thinks it's unconstitutional that you can decline to defend it? Or what if the attorney general thinks it's unconstitutional?"

Srinivasan: "No, no. Of course -- "

Scalia: "Or the solicitor general, is that enough?"

Srinivasan: "28 U.S.C. 530(d) presupposes -- Congress presupposes that there are going to be occasions in which a statute is -- is not defended because of a conclusion by the attorney general that it's unconstitutional."

Scalia: "Oh, it can be either the attorney general or the solicitor ceneral?"

Srinivasan: "It could be, but this is a situation in which the president made the determination."

----

6. Paul Clement, defending the law on behalf of House Republicans, returns to the point about the administration?s enforcement of the law, and suggests that the move is undermining Congress:

Clement: "But what I would say is I just -- I would continue to resist the premise, which is that the House's prerogatives aren't at stake here. The House's single most important prerogative, which is to pass legislation and have that legislation, if it's going to be repealed, only be repealed through a process where the House gets to fully participate."

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7. Justice Ruth Bader Ginsburg cites some of the federal benefits denied to gay couples under DOMA:

Ginsburg: "Mr. Clement, the problem is if we are totally for the states' decision that there is a marriage between two people, for the federal government then to come in to say no joint return, no marital deduction, no Social Security benefits; your spouse is very sick but you can't get leave; people -- if that set of attributes, one might well ask, what kind of marriage is this?"

Clement: "And I think the answer to that, Justice Ginsburg, would be to say that that is a marriage under state law, and I think this court's cases when it talks about the fundamental right to marriage, I take it to be talking about the state law status of marriage; and the question of what does that mean for purposes of federal law has always been understood to be a different matter."

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8. Justice Samuel Alito questions the intent of certain benefits provided by the federal government -- challenging the pro-DOMA side:

Alito: "Suppose we look just at the estate tax provision that's at issue in this case, which provides specially favorable treatment to a married couple as opposed to any other individual or economic unit. What was the purpose of that? Was the purpose of that really to foster traditional marriage, or was Congress just looking for a convenient category to capture households that function as a unified economic unit?"

Clement: "Well, I think for these purposes actually, Justice Alito, if you go back to the beginning of the estate tax deduction, what Congress was trying to do was trying to provide uniform treatment of taxpayers across jurisdictions, and if you look at the brief that Senator Hatch and some other senators filed, they discussed this history, because what was happening in 1948 when this provision was initially put into federal law was you had community property states and common law states, and actually there was much more favorable tax treatment if you were in a community law state than a common law state."

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9. Justice Anthony Kennedy suggests that the federal government should leave questions of marriage to the states. Ginsburg says the benefits at the heart of the argument over DOMA have a wide scope -- with an analogy to a dairy product. And Kagan questions the motives of Congress when it passed DOMA:

Kennedy: "We're helping the states do -- if they do what we want them to, which is -- which is not consistent with the historic commitment of marriage and -- and of questions of -- of the rights of children to the state."

Clement: "With respect, Justice Kennedy, that's not right. No state loses any benefits by recognizing same-sex marriage. Things stay the same. What they don't do is they don't sort of open up an additional class of beneficiaries under their state law for -- that get additional Federal benefits. But things stay the same. And that's why in this sense -- "

Ginsburg: "They're not -- they're not a question of additional benefits. I mean, they touch every aspect of life. Your partner is sick. Social Security. I mean, it's pervasive. It's not as though, well, there's this little Federal sphere and it's only a tax question. It's -- it's -- as Justice Kennedy said, 1,100 statutes, and it affects every area of life. And so he was really diminishing what the state has said is marriage. You're saying, no, state said two kinds of marriage; the full marriage, and then this sort of skim milk marriage."

(Laughter.)

Clement: "With respect, Justice Ginsburg, that's not what the federal government is saying. The federal government is saying that within its own realm in federal policies, where we assume that the federal government has the authority to define the terms that appear in their own statute, that in those areas, they are going to have their own definition. And that's -- "

Kagan: "Mr. Clement, for the most part and historically, the only uniformity that the federal government has pursued is that it's uniformly recognized the marriages that are recognized by the state. So, this was a real difference in the uniformity that the federal government was pursuing. And it suggests that maybe something -- maybe Congress had something different in mind than uniformity. So we have a whole series of cases which suggest the following: Which suggest that when Congress targets a group that is not everybody's favorite group in the world, that we look at those cases with some -- even if they're not suspect -- with some rigor to say, do we really think that Congress was doing this for uniformity reasons, or do we think that Congress's judgment was infected by dislike, by fear, by animus, and so forth? I guess the question that this statute raises, this statute that does something that's really never been done before, is whether that sends up a pretty good red flag that that's what was going on."

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10. Later, Kagan presses Clement directly on the intent of Congress.

Clement: "Up until 1996, it essentially has it both ways: Every state has the traditional definition. Congress knows that's the definition that's embedded in every federal law. So that's fine. We can defer. OK. 1996 -- "

Kagan: "Well, is what happened in 1996 -- and I'm going to quote from the House report here -- is that "Congress decided to reflect an honor of collective moral judgment and to express moral disapproval of homosexuality." Is that what happened in 1996?"

Clement: "Does the House report say that? Of course, the House Report says that. And if that's enough to invalidate the statute, then you should invalidate the statute. But that has never been your approach, especially under rational basis or even rational basis-plus, if that is what you are suggesting."

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11. Solicitor General Donald Verrilli, also representing the administration, lays out his case against DOMA, and the chief justice poses a hypothetical. Section 3 is a reference to part of the law that says that marriage shall be considered a legal union between one man and one woman:

Verrilli: "The equal protection analysis in this case should focus on two fundamental points: First, what does Section 3 do; and second, to whom does Section 3 do it? What Section 3 does is exclude from an array of federal benefits lawfully married couples. That means that the spouse of a soldier killed in the line of duty cannot receive the dignity and solace of an official notification of next of kin."

Roberts: "Suppose your -- you agree that Congress could go the other way, right? Congress could pass a new law today that says, We will give federal benefits. When we say 'marriage' in federal law, we mean committed same-sex couples as well, and that could apply across the board. Or do you think that they couldn't do that?"

Verrilli: "We think that wouldn't raise an equal protection problem like this statute does, Mr. Chief Justice."

Source: http://feeds.nbcnews.com/c/35002/f/653381/s/2a10b70c/l/0Lusnews0Bnbcnews0N0C0Inews0C20A130C0A30C270C17488910A0E110Ekey0Emoments0Efrom0Ethe0Eargument0Eover0Ethe0Edefense0Eof0Emarriage0Eact0Dlite/story01.htm

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Wednesday, March 13, 2013

Prediction of seasonal flu strains improves chances of universal vaccine

Wednesday, March 13, 2013

Researchers have determined a way to predict and protect against new strains of the flu virus, in the hope of improving immunity against the disease.

Influenza is a rapidly spreading acute respiratory disease. Worldwide, annual seasonal epidemics of the flu result in 3-5 million cases of severe illness, and up to 500 000 deaths. A newly emerged virus can spread across 74 countries in 2 months.

The study led by the University of Melbourne with Monash University and international colleagues has found how to predict and potentially stop the mutating cells of the influenza virus, which escape our bodies' white blood cells (T cell) immunity.

Senior author, Associate Professor Katherine Kedzierska from the Department of Microbiology and Immunology at the University of Melbourne said the finding may lead to a new universal influenza vaccine to better protect against both seasonal and pandemic outbreaks.

This research, published in PNAS today, will also help researchers understand T cell immunity against other viral infections such as HIV, Hepatitis C and tumours.

"The introduction of a new influenza strain into human circulation leads to a rapid global spread of the virus due to minimal antibody immunity," Assoc Prof Kedzierska said.

"White blood cells called T cells are highly efficient in fighting influenza virus infection. Thus, established T cell immunity towards particular viral regions can provide 'universal' immunity against distinct seasonal and pandemic influenza strains.

"However, influenza viruses can mutate their genes to escape efficient T cells. This constitutes a major problem for a design of a universal vaccine.

In the current paper, researchers have unraveled how influenza viruses evade T cell immunity by introducing specific mutations within the viral proteins.

Professor Peter Doherty, a lead author of the study from the University of Melbourne said predicting and designing vaccines to protect against such mutants can promote T cell immunity.

"The studies suggested that an influenza vaccine that targets T cells and recognizes distinct virus strains could provide universal immunity against any future influenza strain," he said.

###

University of Melbourne: http://www.unimelb.edu.au

Thanks to University of Melbourne for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/127268/Prediction_of_seasonal_flu_strains_improves_chances_of_universal_vaccine

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No attention-boosting drugs for healthy kids, doctors urge

Mar. 13, 2013 ? The American Academy of Neurology (AAN), the world's largest professional association of neurologists, is releasing a position paper on how the practice of prescribing drugs to boost cognitive function, or memory and thinking abilities, in healthy children and teens is misguided.

The statement is published in the March 13, 2013, online issue of Neurology, the medical journal of the American Academy of Neurology.

This growing trend, in which teens use "study drugs" before tests and parents request ADHD drugs for kids who don't meet the criteria for the disorder, has made headlines recently in the United States. The Academy has spent the past several years analyzing all of the available research and ethical issues to develop this official position paper.

"Doctors caring for children and teens have a professional obligation to always protect the best interests of the child, to protect vulnerable populations, and prevent the misuse of medication," said author William Graf, MD, of Yale University in New Haven, Conn., and a member of the American Academy of Neurology. "The practice of prescribing these drugs, called neuroenhancements, for healthy students is not justifiable."

The statement provides evidence that points to dozens of ethical, legal, social and developmental reasons why prescribing mind-enhancing drugs, such as those for ADHD, for healthy people is viewed differently in children and adolescents than it would be in functional, independent adults with full decision-making capacities. The Academy has a separate position statement that addresses the use of neuroenhancements in adults.

The article notes many reasons against prescribing neuroenhancement including: the child's best interest; the long-term health and safety of neuroenhancements, which has not been studied in children; kids and teens may lack complete decision-making capacities while their cognitive skills, emotional abilities and mature judgments are still developing; maintaining doctor-patient trust; and the risks of over-medication and dependency.

"The physician should talk to the child about the request, as it may reflect other medical, social or psychological motivations such as anxiety, depression or insomnia. There are alternatives to neuroenhancements available, including maintaining good sleep, nutrition, study habits and exercise regimens," said Graf.

The statement had no industry sponsors.

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The above story is reprinted from materials provided by American Academy of Neurology (AAN).

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. William D. Graf, Saskia K. Nagel, Leon G. Epstein, Geoffrey Miller, Ruth Nass, and Dan Larriviere. Pediatric neuroenhancement Ethical, legal, social, and neurodevelopmental implications. Neurology, 2013 DOI: 10.1212/WNL.0b013e318289703b

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/living_well/~3/lct30rq7sYE/130313182022.htm

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Tuesday, March 12, 2013

Store donated blood for more than 3 weeks? Say NO (nitric oxide)

Mar. 10, 2013 ? Transfusion of donated blood more than three weeks old results in impaired blood vessel function, a new study of hospital patients shows.

Blood banks now consider six weeks to be the maximum permitted storage time of blood for use in transfusion, but recent studies have suggested transfusing blood stored for more than a few weeks has adverse effects in patients undergoing cardiac surgery or critical care.

The new finding suggests a mechanism explaining why older blood might be detrimental to patient health: a deficiency in nitric oxide, a short-lived chemical messenger that relaxes blood vessels.

The results are being presented at the American College of Cardiology meeting in San Francisco. The presenter is cardiovascular research fellow Robert Neuman, MD. Senior authors include Arshed Quyyumi, MD, professor of medicine and director of the Emory Clinical Cardiovascular Research Institute, and John Roback, MD, PhD, associate professor of pathology and laboratory medicine and medical director of the Emory University Hospital blood bank.

In the current study, 43 patients at Emory University Hospital were set to receive cross-matched red blood cells for clinical indications. Members of the group were in hospital for various reasons, such as cancer treatment and surgery. They were randomly chosen to receive either fresh (less than ten days old) or aged (more than three weeks old) red blood cells. On average, they received the equivalent of two units. A unit is 450 milliliters of blood.

Neuman and his colleagues tested blood vessel function by measuring flow-mediated dilation (FMD). By ultrasound, they tested how much a blood vessel in the arm opens up after a blood pressure cuff is first tightened then removed. Flow-mediated dilation is an indicator of the health of the endothelial lining of the blood vessels and is a process that is dependent on nitric oxide.

Healthy, younger individuals can have flow-mediated dilation of up to 10 percent -- the average for the hospitalized group was 5 percent. Patients receiving aged blood saw their FMD halved to 2.4 percent 24 hours after the transfusion, while patients receiving fresh blood saw no significant change in FMD.

This effect of older blood on blood vessel function is similar in size to that of eating a fatty meal (temporary), or the longterm effects of a cardiovascular disease risk factor such as smoking or diabetes.

Healthy flow-mediated dilation reflects sufficient production of nitric oxide, which is generated by the blood vessels' endothelial lining and causes them to relax. Nitric oxide is also important for delivery of oxygen by hemoglobin. Red blood cells carry nitric oxide bound to hemoglobin, and play a critical role in recycling the nitric oxide. Over time in storage, the nitric oxide is lost. Transfused red blood cells last a couple months in the patient. The Emory team did not measure FMD beyond 24 hours.

The so-called "red blood cell storage lesion" consists of several changes including oxidation, disruption of cellular structures, and loss of other chemicals such as the energy currency ATP and the hemoglobin regulator 2,3-diphosphoglycerate. A recent study has also shown that red blood cells stored for more than three weeks lose physical flexibility.

Thus, loss of nitric oxide is probably not the only important change, but it may be significant in terms of effects on cardiovascular health, the authors argue.

"Aside from the direct infusion of nitric oxide-deficient blood, we may be also seeing an indirect effect from other aspects of storage that impact nitric oxide availability and endothelial function such as increased inflammation triggered by aged blood," Neuman says.

A 2008 study published in the New England Journal of Medicine found that cardiac surgery patients receiving older blood had a higher risk of dying in the hospital, and were more likely to need ventilation support or have sepsis or kidney failure. Two large-scale clinical trials (links below) are addressing the issue of the maximum time blood should be stored.

Although blood banks tend to use a "first-in, first-out" policy, limiting storage time could reduce the blood supply. One possibility could be to reserve fresh blood for those patients at most risk of cardiovascular problems, Neuman says.

Another way that nitric oxide deficiency could be remedied is with an additive such as nitrite, which the body uses as a storage reservoir for nitric oxide, or some other preservative. Red blood cells are now stored in a solution with glucose, anticoagulant and acidity buffering properties.

"There is a lot of information that blood that has been stored for a while can cause problems for patients," Neuman says. "This starts to answer the question: what is causing the problem?"

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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/Efp2V2XujIk/130310164225.htm

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Baylor still No. 1 in AP women's basketball poll

Baylor guard Kimetria Hayden (1) and center Brittney Griner (42) defend against a drive by Oklahoma State forward Liz Donohoe (4) in the second half of an NCAA college basketball game in the Big 12 women's tournament Sunday, March 10, 2013, in Dallas. Donohoe had 20-points in the 77-69 loss to Baylor. (AP Photo/Tony Gutierrez)

Baylor guard Kimetria Hayden (1) and center Brittney Griner (42) defend against a drive by Oklahoma State forward Liz Donohoe (4) in the second half of an NCAA college basketball game in the Big 12 women's tournament Sunday, March 10, 2013, in Dallas. Donohoe had 20-points in the 77-69 loss to Baylor. (AP Photo/Tony Gutierrez)

Baylor center Brittney Griner (42) goes up for a shot over Oklahoma State's Tiffany Bias (3) and Kendra Suttles (31) in the second half of an NCAA college basketball game in the Big 12 women's tournament Sunday, March 10, 2013, in Dallas. Griner had a game-high 30-points in the 77-69 Baylor win. (AP Photo/Tony Gutierrez)

Oklahoma State forward Toni Young, center, dives to grab a loose ball against Baylor' Jordan Madden, right, as Baylor's Brittney Griner, top, left, Alexis Prince (12) and Oklahoma State's Kendra Suttles (31) watch in the second half of an NCAA college basketball game in the Big 12 Conference women's tournament Sunday, March 10, 2013, in Dallas. Baylor won 77-69. (AP Photo/Tony Gutierrez)

Baylor guard Jordan Madden, bottom left, looks toward an official waiting for a call as Oklahoma State forward Toni Young (15) scrambles on the floor for a turnover by Baylor in the second half of an NCAA college basketball game in the Big 12 women's tournament Sunday, March 10, 2013, in Dallas. Baylor's Brittney Griner, top left, and Alexis Prince, top right, watch in the 77-69 Baylor win. (AP Photo/Tony Gutierrez)

Baylor head coach Kim Mulkey and the bench celebrate a score by Baylor's Brooklyn Pope (32) in the second half of an NCAA college basketball game against Oklahoma State in the Big 12 women's tournament Sunday, March 10, 2013, in Dallas. Baylor won 77-69. (AP Photo/Tony Gutierrez)

Baylor remains No. 1 in The Associated Press women's basketball poll for a 10th consecutive week.

The Lady Bears received all 40 first-place votes for the third straight week and have won 48 straight Big 12 regular-season and tournament games. They play No. 23 Iowa State for the conference title Monday night.

The top four stayed the same, with Notre Dame, Connecticut and Stanford following Baylor. The Irish and Huskies advanced to Monday night's Big East tournament semifinals. Stanford clinched the Pac-12 tournament Sunday night and won't play again until NCAA tournament.

Duke, California, Penn State, Texas A&M and Tennessee round out the first 10. The Aggies made the biggest leap moving up 10 spots after winning the SEC tournament.

Purdue rejoined the poll at No. 21 after taking the Big Ten tournament. Toledo and LSU fell out.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-03-11-T25-Women's%20Bkb%20Poll/id-b6f5226569e545a6898121752448f77f

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Monday, March 11, 2013

Pad & Quill introduce the Aria for iPad mini

Pad & Quill are known for their beautifully crafted cases that lend a hand-bound book appearance to your tablets. ?They have turned their attention to the iPad mini with their new Aria case. ?The case is handmade with bookbinding techniques from full-grain American leather. ?The leather cover features an embossed design on the front and [...]

Source: http://the-gadgeteer.com/2013/03/11/pad-quill-introduce-the-aria-for-ipad-mini/

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Friday, March 8, 2013

PFT: Hasselbeck ready for pay cut or release

Matt HasselbeckAP

Add Titans backup quarterback Matt Hasselbeck to the pay-cut-or-be-cut club, and at least the veteran passer understands exactly what?s going on.

Hasselbeck said his agent and the Titans are still talking about what his contract will look like, understanding it might not necessarily be the $5.5 million on base salary he stands to collect now. If they can?t agree, he figures he?ll have to look elsewhere.

?Well, yeah, if we can?t come to an agreement, I guess that?s what they?d have to do. That?s just how it goes,? Hasselbeck told John Glennon of the Tennesseean. ?Right now I?m working out hard, getting prepared and ready, trying to have the best year I can. Again, I?m really hopeful that it?s here, but I understand that some things are more out of your control.?

Unlike when he walked in the door two years ago, he?s entrenched as the backup behind Jake Locker, and the Titans are leaning toward the compensation matching that status.

?I believe in what we?re doing. I believe in [general manager] Ruston Webster and [coach] Mike Munchak. I believe in my teammates like Jake,? Hasselbeck said. ?But , . . . anything can happen. Surprises come. We?ll see. I don?t know. Some of it is out of my hands, and some of it is in my hands.

?I?m really wanting to be part of something special, part of something good, something I can be proud of and things like that will far outweigh salary or whatever. My feelings for wanting to stay haven?t changed. My feelings for how easy it?s been for us to plug into this community in Nashville haven?t changed.?

While he?s not going to play for free, Hasselbeck?s approach to this makes it more likely a deal gets worked out that keeps him making a living wage, while the team re-adjusts the books to reflect his status on the depth chart.

Source: http://profootballtalk.nbcsports.com/2013/03/08/matt-hasselbeck-understands-its-pay-cut-or-be-cut/related/

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